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New sipanmycin analogues generated by combinatorial biosynthesis and mutasynthesis approaches relying on the substrate flexibility of key enzymes in the biosynthetic pathway [2020]
Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin [2020]
Fine-tuning the regulation of Cas9 expression levels for efficient CRISPR-Cas9 mediated recombination in Streptomyces [2020]
Discovery of Cryptic Largimycins in Streptomyces Reveals Novel Biosynthetic Avenues Enriching the Structural Diversity of the Leinamycin Family [2020]
A plasmid-encoded fetmp-fls iron uptake system confers selective advantages to salmonella enterica serovar typhimurium in growth under iron-restricted conditions and for infection of mammalian host cells [2020]
The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042 [2019]
Desertomycin G, a new antibiotic with activity against mycobacterium tuberculosis and human breast tumor cell lines produced by streptomyces althioticus MSM3, isolated from the cantabrian sea intertidal macroalgae ulva sp. [2019]
Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches [2018]
Searching for glycosylated natural products in actinomycetes and identification of novel macrolactams and angucyclines [2018]
New insights into the biosynthesis pathway of polyketide alkaloid argimycins P in Streptomyces argillaceus [2018]
New 3-Hydroxyquinaldic Acid Derivatives from Cultures of the Marine Derived Actinomycete Streptomyces cyaneofuscatus M-157 [2018]
Inhibition of FLT3 and PIM Kinases by EC-70124 Exerts Potent Activity in Preclinical Models of Acute Myeloid Leukemia [2018]
Cooperative involvement of glycosyltransferases in the transfer of amino sugars during the biosynthesis of the macrolactam sipanmycin by Streptomyces sp. strain CS149 [2018]
Combining raw and compositional data to determine the spatial patterns of Potentially Toxic Elements in soils [2018]
Characterization of the jomthonic acids biosynthesis pathway and isolation of novel analogues in streptomyces caniferus GUA-06-05-006A [2018]
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